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    Retinal image analysis

    Biomarker identification

    Early disease detection


Retinal screening will become part of a regular health checkup for early disease identification and management. Retinal screening can assess the impact of risk factors – including diabetes, smoking, obesity, high cholesterol, hypertension and inactivity – in the general population. It contributes to evidence-based population health programs. Retinal screening is valuable for predicting and preventing diseases.

Family and physiscian

We develop algorithms for accurate analysis of retinal images. We use state-of-the-art methods such as deep learning for extracting novel information from images. Our data analysis workflows combine information from retinal images with personal data for biomarker identification and characterization of disease trajectory. We have software for superior grading of retinal microvasculature.

Data science

Your health in the blink of an eye.

Meet IFLEXIS software

IFLEXIS is your valuable software when you are investigating disease development and progression or when you are doing population health studies. IFLEXIS software analyses the vascular pattern of retinal images and quantifies dimensions of retinal blood vessels. These vessel widths are accepted measures to evaluate an individual’s cardiovascular risk. In addition, IFLEXIS characterizes the vascular network with an extensive set of branching characteristics, tortuosity parameters and fractal dimensions. IFLEXIS has already many useful features and more are currently being added:

  • Segmentation and skeletonisation
  • Optic disc and macula detection
  • Calculation of vessel dimensions
  • Detailed analysis of vessel network
  • Image registration & accurate time course analysis
  • Compatible with different cameras
  • Single and batch import of images
  • Upload of metadata
  • Data export in various file formats

IFLEXIS retina desktop software

download the IFLEXIS product flyer here.


The function of the retina is to convert the incoming light into a neural signal that is further propagated to the visual cortex for processing visual information. Simply said, the retina allows us to see the outside world.


An individual’s retina can be easily visualized with fundus photography. This digital image can be used to identify diseases of the eye such as macular degeneration, glaucoma and diabetic retinopathy. Early disease identification and disease stages can be quantified by changes in retina landmarks (optic disc, macula and vascular pattern) and clinical events.


The retina is an unique site for mapping the microvasculature in a fast and convenient way. Moreover, retinal microvasculature shows homology with microvascular beds found in the heart, lungs and brain. Systemic diseases cause parallel changes in the retinal microvasculature. Epidemiological studies demonstrate that dimensions of retinal vessels and vessel network change in diabetes, coronary heart disease, stroke and Alzheimer’s disease. The retina is a true window to the heart and the brain.

About us

The team is a multidisciplinary team with expertise in biomedicine and life sciences, machine learning and health-IT. The team is part of the Health Unit of VITO, Flanders’ research and technology organization on cleantech and sustainable development. The Health unit of VITO is an applied research group working at the forefront of research into precision medicine. It is developing biomarkers for early diagnosis, screening and prognosis.



Get in touch to know more about our activities and to start using IFLEXIS software.